TY - JOUR T1 - Bradycardia associated with pegylated liposomal doxorubicin administration: a case report JF - European Journal of Hospital Pharmacy JO - Eur J Hosp Pharm SP - 128 LP - 130 DO - 10.1136/ejhpharm-2015-000817 VL - 24 IS - 2 AU - Zhaolu Xie AU - Wei Wu AU - Haiyan Xing AU - Yongqing Cai AU - Xianfeng Wang AU - Jianhong Chen Y1 - 2017/03/01 UR - http://ejhp.bmj.com/content/24/2/128.abstract N2 - The cardiotoxicity of doxorubicin is dose dependent and progressive, but its mechanisms remain unclear. Measures to prevent the cardiotoxicity of doxorubicin have had limited success. We report here on a patient who had received intravenous infusion of pegylated liposomal doxorubicin and developed sinus bradycardia despite the prior administration of the iron-chelating agent, dexrazoxane. The adverse effect of pegylated liposomal doxorubicin might be due to the difference in metabolic related genes for anthracyclines. Therefore, monitoring the cardiac condition of patients who receive doxorubicin treatment, even at low doses, is highly recommended. ER -