@article {Postejhpharm-2016-001128, author = {Titiaan E Post and Ingrid M C Kamerling and Richard C J M van Rossen and Jacobus Burggraaf and Jasper Stevens and Anneke C Dijkmans and Harry G M Heijerman and Daan J Touw and Annelies J van Velzen and Erik B Wilms}, title = {Colistin methanesulfonate infusion solutions are stable over time and suitable for home administration}, elocation-id = {ejhpharm-2016-001128}, year = {2017}, doi = {10.1136/ejhpharm-2016-001128}, publisher = {BMJ Specialist Journals}, abstract = {The stability of colistin methanesulfonate (CMS) was determined in quadruplicate in elastomeric home infusion pumps containing 1, 2 or 3 MU CMS and in infusion bags with 2 MU CMS all in 100 mL normal saline. Infusions were stored at room temperature (20{\textdegree}C{\textendash}24{\textdegree}C) with or without exposure to natural light or refrigerated (4{\textdegree}C{\textendash}8{\textdegree}C) and protected from light up to 2 weeks. In the initial solution of 2 MU CMS in 100 mL saline sampled immediately after reconstitution and dilution, 1.5\% of CMS was hydrolysed to colistin. When stored at room temperature and exposed to natural light, colistin concentration in elastomeric infusion pumps increased to 2.6\% in 8 days and to 2.1\% when stored at 4{\textdegree}C. CMS stability increases at lower temperatures and higher concentrations. Based on the current data, chemical stability of CMS infusion solution is sufficient for a shelf life of 7 days refrigerated plus 1 day at room temperature.}, issn = {2047-9956}, URL = {https://ejhp.bmj.com/content/early/2017/03/18/ejhpharm-2016-001128}, eprint = {https://ejhp.bmj.com/content/early/2017/03/18/ejhpharm-2016-001128.full.pdf}, journal = {European Journal of Hospital Pharmacy} }