TY - JOUR T1 - Betamethasone dipropionate compounding for cutaneous T-cell lymphoma management JF - European Journal of Hospital Pharmacy JO - Eur J Hosp Pharm SP - 43 LP - 47 DO - 10.1136/ejhpharm-2016-001052 VL - 25 IS - 1 AU - Patrícia Trindade AU - Alice Gelpi AU - Ana Salgado AU - Joana Marto AU - Paula Machado AU - Dinis Mateus AU - Humberto Gonçalves AU - M Fernanda Sachse AU - António Melo Gouveia AU - Helena Ribeiro Y1 - 2018/01/01 UR - http://ejhp.bmj.com/content/25/1/43.abstract N2 - Background Primary cutaneous lymphomas (extranodular non-Hodgkin lymphomas) are rare (incidence 1:100 000). Mycosis fungoides is the most common cutaneous T-cell lymphoma (CTCL) subtype. Treatment options are based on the diagnosis and the stage of the disease. Skin-directed therapies are useful for the initial stages and include topical treatments such as corticosteroids. Betamethasone dipropionate (BD) is a synthetic glucocorticoid with high anti-inflammatory activity, potency and immunosuppressant effects. It is used for topical treatment of CTCL within the following dosage 0.025–0.1% (w/w). In the Portuguese market only one topical cream contains BD at 0.05% (w/w).Objectives To develop a new and stable emulsion containing 0.1% of BD.Methods To accomplish this aim, development, stability, in vitro release and clinical studies of a new topical water-in-oil emulsion containing BD 0.1% w/w were assessed for the topical treatment of CTCL.Results The three batches prepared were physically, chemically and microbiologically stable over a period of 90 days. 40% of BD was released over 6 hours and evaluation of skin lesions showed a favourable clinical effect (less itching, less infiltration, fewer patches and a reduced area of plaque).Conclusions The clinical results show the effective cutaneous improvement of skin barrier conditions during the study. ER -