PT  - JOURNAL ARTICLE
AU  - Javier Sánchez-Rubio Ferrández
AU  - Rocío Vázquez Sánchez
AU  - Damián Córdoba Díaz
AU  - Manuel Córdoba Díaz
AU  - María Carmen Lozano Estevan
AU  - Teresa Molina García
TI  - Stability of daptomycin reconstituted vials and infusion solutions
AID  - 10.1136/ejhpharm-2015-000784
DP  - 2018 Mar 01
TA  - European Journal of Hospital Pharmacy
PG  - 107--110
VI  - 25
IP  - 2
4099  - http://ejhp.bmj.com/content/25/2/107.short
4100  - http://ejhp.bmj.com/content/25/2/107.full
SO  - Eur J Hosp Pharm2018 Mar 01; 25
AB  - Objectives Daptomycin is a cyclic lipopeptide with selective action against drug-resistant Gram-positive bacteria. The stability of daptomycin solutions in different containers while stored at different temperatures was assessed.Methods Daptomycin vials were reconstituted with NaCl (50 mg/mL). Daptomycin infusion solutions (5.6 and 14.0 mg/mL) were prepared in polypropylene infusion bags. All test solutions were stored either under refrigeration or at room temperature over 7 days. Samples were withdrawn on days 0, 2, 4 and 7 and assayed in triplicate using a stability-indicating high-performance liquid chromatography (HPLC) method.Results The HPLC analysis revealed no significant loss in daptomycin concentration in vials or bags when stored at 2–8°C. All samples remained clear and colourless and there were no significant changes in pH throughout the study period.Conclusions Reconstituted daptomycin vials (50 mg/mL) and infusion bags (5.6 and 14 mg/mL) were found to be physicochemically stable over a period of 1 week when stored at 2–8°C.