TY - JOUR T1 - Stability of daptomycin reconstituted vials and infusion solutions JF - European Journal of Hospital Pharmacy JO - Eur J Hosp Pharm SP - 107 LP - 110 DO - 10.1136/ejhpharm-2015-000784 VL - 25 IS - 2 AU - Javier Sánchez-Rubio Ferrández AU - Rocío Vázquez Sánchez AU - Damián Córdoba Díaz AU - Manuel Córdoba Díaz AU - María Carmen Lozano Estevan AU - Teresa Molina García Y1 - 2018/03/01 UR - http://ejhp.bmj.com/content/25/2/107.abstract N2 - Objectives Daptomycin is a cyclic lipopeptide with selective action against drug-resistant Gram-positive bacteria. The stability of daptomycin solutions in different containers while stored at different temperatures was assessed.Methods Daptomycin vials were reconstituted with NaCl (50 mg/mL). Daptomycin infusion solutions (5.6 and 14.0 mg/mL) were prepared in polypropylene infusion bags. All test solutions were stored either under refrigeration or at room temperature over 7 days. Samples were withdrawn on days 0, 2, 4 and 7 and assayed in triplicate using a stability-indicating high-performance liquid chromatography (HPLC) method.Results The HPLC analysis revealed no significant loss in daptomycin concentration in vials or bags when stored at 2–8°C. All samples remained clear and colourless and there were no significant changes in pH throughout the study period.Conclusions Reconstituted daptomycin vials (50 mg/mL) and infusion bags (5.6 and 14 mg/mL) were found to be physicochemically stable over a period of 1 week when stored at 2–8°C. ER -