TY - JOUR T1 - Physicochemical stability of oxycodone-ketamine solutions in polypropylene syringe and polyvinyl chloride bag for patient-controlled analgesia use JF - European Journal of Hospital Pharmacy JO - Eur J Hosp Pharm SP - 214 LP - 217 DO - 10.1136/ejhpharm-2016-000965 VL - 25 IS - 4 AU - Mikaël Daouphars AU - Charles-Henri Hervouët AU - Pierre Bohn AU - Delphine Martin AU - Jean Rouvet AU - Florence Basuyau AU - Rémi Varin Y1 - 2018/07/01 UR - http://ejhp.bmj.com/content/25/4/214.abstract N2 - Objectives The study evaluated the stability of three combinations of oxycodone and ketamine diluted in normal saline (NS) after storage for 7 days at 23°C and exposed to light.Methods The stability of three mixtures of oxycodone and ketamine (oxycodone 0.4 mg/mL+ketamine 40 mg/mL, oxycodone 10 mg/mL+ketamine 0.1 mg/mL and oxycodone 10 mg/mL+ketamine 40 mg/mL) in NS stored in a polypropylene syringe and a polyvinyl chloride (PVC) bag was studied. The physical characteristics, including pH, colour and precipitation, were evaluated. The samples were analysed in triplicate by a stability-indicating high-performance liquid chromatography method.Results There was no significant change in the pH values of any solution. No precipitation or change in colour was observed. All formulations maintained more than 95% of the initial concentration of each drug on day 7. No trace of degradation products was detected.Conclusions Ketamine (0.1–40 mg/mL) combined with oxycodone (0.4–10 mg/mL) is physically compatible and chemically stable for 7 days when diluted with NS, packaged in polypropylene syringe or PVC bag and stored at 23°C. ER -