RT Journal Article
SR Electronic
T1 Stability and compatibility of ondansetron with haloperidol in parenteral admixtures
JF European Journal of Hospital Pharmacy
JO Eur J Hosp Pharm
FD British Medical Journal Publishing Group
SP 200
OP 203
DO 10.1136/ejhpharm-2016-001200
VO 25
IS 4
A1 Gabriel Estan-Cerezo
A1 Carmen Matoses-Chirivella
A1 Leticia Soriano-Irigaray
A1 Ana Cristina Murcia-López
A1 Francisco José Rodríguez-Lucena
A1 Andrés Navarro-Ruiz
YR 2018
UL http://ejhp.bmj.com/content/25/4/200.abstract
AB Background The chemical stability of coadministered ondansetron (OND) and haloperidol (HAL) in parenteral admixtures has not been described yet.Objective The aim of the present work is to study the chemical stability and the compatibility of OND and HAL admixtures.Methods Normal saline solution and dextrose were used to prepare the admixture solutions of the drugs; the materials of the containers were the original plastic bags of the diluents and the stability was studied at 20°C. Compatibility was studied by visual inspection of no colour change and turbidity or precipitation appearance. The concentration of the drugs was studied by ultraviolet detection high-performance liquid chromatography. The method was validated following the Food and Drug Administration and European Medicines Agency guidelines, and the assay enables the measurement of both drugs with a linear calibration curve (r=0.999) over the concentration range 10–100 µg/mL, with acceptable values of linearity, precision and accuracy. Darunavir was used as internal standard.Results Most of the admixtures have an adequate concentration until 24 hours(less than 10% of loss). 25% of the samples show a higher loss at 24 hours, and the chemical stability of these samples is 12 hours.Conclusions The stability and compatibility of OND and HAL in the coadministered admixtures in Viaflo plastic bags with normal saline or dextrose are suggested at 12 hours.