PT - JOURNAL ARTICLE AU - María Espinosa-Bosch AU - Fuensanta Sanchez-Rojas AU - Catalina Bosch-Ojeda TI - Stability of mixtures of ondansetron and haloperidol stored in infusors at different temperatures AID - 10.1136/ejhpharm-2017-001412 DP - 2018 Oct 01 TA - European Journal of Hospital Pharmacy PG - e134--e138 VI - 25 IP - e2 4099 - http://ejhp.bmj.com/content/25/e2/e134.short 4100 - http://ejhp.bmj.com/content/25/e2/e134.full SO - Eur J Hosp Pharm2018 Oct 01; 25 AB - Background and objective Mixing different drugs for use in continuous infusion systems is a common practice in palliative care, but analytical study of compatibility and stability is not always available. The objective of this work is to study the stability of solutions of ondansetron and haloperidol at different concentrations and temperatures all prepared in 0.9% NaCl and stored in infusors, with all cases protected from light.Materials and methods The high performance liquid chromatography-Ultraviolet (HPLC-UV) method was employed for the determination of the drugs. The concentrations of the admixtures were 0.15–0.25 mg/mL and 0.3–0.4 mg/mL of haloperidol and ondansetron, respectively, with a storage temperature of 25°C and 37°C.Results All solutions were initially clear and colourless, but visible particles appear, in all cases, into the infusers after 2 days since their preparation.Conclusion From the results obtained we can conclude that the mixtures prepared in the conditions previously described are stable less than 48 hours.