PT  - JOURNAL ARTICLE
AU  - Post, Titiaan E
AU  - Kamerling, Ingrid M C
AU  - van Rossen, Richard C J M
AU  - Burggraaf, Jacobus
AU  - Stevens, Jasper
AU  - Dijkmans, Anneke C
AU  - Heijerman, Harry G M
AU  - Touw, Daan J
AU  - van Velzen, Annelies J
AU  - Wilms, Erik B
TI  - Colistin methanesulfonate infusion solutions are stable over time and suitable for home administration
AID  - 10.1136/ejhpharm-2016-001128
DP  - 2018 Nov 01
TA  - European Journal of Hospital Pharmacy
PG  - 337--339
VI  - 25
IP  - 6
4099  - http://ejhp.bmj.com/content/25/6/337.short
4100  - http://ejhp.bmj.com/content/25/6/337.full
SO  - Eur J Hosp Pharm2018 Nov 01; 25
AB  - The stability of colistin methanesulfonate (CMS) was determined in quadruplicate in elastomeric home infusion pumps containing 1, 2 or 3 MU CMS and in infusion bags with 2 MU CMS all in 100 mL normal saline. Infusions were stored at room temperature (20°C–24°C) with or without exposure to natural light or refrigerated (4°C–8°C) and protected from light up to 2 weeks. In the initial solution of 2 MU CMS in 100 mL saline sampled immediately after reconstitution and dilution, 1.5% of CMS was hydrolysed to colistin. When stored at room temperature and exposed to natural light, colistin concentration in elastomeric infusion pumps increased to 2.6% in 8 days and to 2.1% when stored at 4°C. CMS stability increases at lower temperatures and higher concentrations. Based on the current data, chemical stability of CMS infusion solution is sufficient for a shelf life of 7 days refrigerated plus 1 day at room temperature.