RT Journal Article SR Electronic T1 Colistin methanesulfonate infusion solutions are stable over time and suitable for home administration JF European Journal of Hospital Pharmacy JO Eur J Hosp Pharm FD British Medical Journal Publishing Group SP 337 OP 339 DO 10.1136/ejhpharm-2016-001128 VO 25 IS 6 A1 Post, Titiaan E A1 Kamerling, Ingrid M C A1 van Rossen, Richard C J M A1 Burggraaf, Jacobus A1 Stevens, Jasper A1 Dijkmans, Anneke C A1 Heijerman, Harry G M A1 Touw, Daan J A1 van Velzen, Annelies J A1 Wilms, Erik B YR 2018 UL http://ejhp.bmj.com/content/25/6/337.abstract AB The stability of colistin methanesulfonate (CMS) was determined in quadruplicate in elastomeric home infusion pumps containing 1, 2 or 3 MU CMS and in infusion bags with 2 MU CMS all in 100 mL normal saline. Infusions were stored at room temperature (20°C–24°C) with or without exposure to natural light or refrigerated (4°C–8°C) and protected from light up to 2 weeks. In the initial solution of 2 MU CMS in 100 mL saline sampled immediately after reconstitution and dilution, 1.5% of CMS was hydrolysed to colistin. When stored at room temperature and exposed to natural light, colistin concentration in elastomeric infusion pumps increased to 2.6% in 8 days and to 2.1% when stored at 4°C. CMS stability increases at lower temperatures and higher concentrations. Based on the current data, chemical stability of CMS infusion solution is sufficient for a shelf life of 7 days refrigerated plus 1 day at room temperature.