RT Journal Article
SR Electronic
T1 Application of vancomycin in patients with augmented renal clearance
JF European Journal of Hospital Pharmacy
JO Eur J Hosp Pharm
FD British Medical Journal Publishing Group
SP ejhpharm-2018-001781
DO 10.1136/ejhpharm-2018-001781
A1 Yang Chu
A1 Yifan Luo
A1 Mingyan Jiang
A1 Baosen Zhou
YR 2019
UL http://ejhp.bmj.com/content/early/2019/01/09/ejhpharm-2018-001781.abstract
AB Objective To analysethe influence of factors on the steady-state trough concentration (Ctrough) of vancomycin, especially in patients with augmented renal clearance, and to provide a reference for clinical application.Methods Data on patient demographics, routine blood examination, hepatic function and kidney function were collected from May 2013 to October 2016. A total of 292 patients were enrolled and correlations between Ctroughof vancomycin and other test indices were analysed by SPSS software.Results Vancomycin Ctrough was mainly affected by age and log(Ctrough) showed a good cubic correlation with age (R2=0.999) in patients with augmented renal clearance.Conclusions Inpatients with augmented renal clearance,vancomycin Ctrough was mainly affected by age. Clinicians and pharmacists should adjust the dosage regimen in a timely manner based on therapeutic drug monitoringand these influencing factors.