RT Journal Article
SR Electronic
T1 5PSQ-014 Novel oral anticoagulants vs vitamin K antagonists: a cost analysis
JF European Journal of Hospital Pharmacy
JO Eur J Hosp Pharm
FD British Medical Journal Publishing Group
SP A208
OP A208
DO 10.1136/ejhpharm-2019-eahpconf.447
VO 26
IS Suppl 1
A1 Tonelli, M
A1 Barila’, DA
A1 Caiazza, E
A1 Scaldaferri, M
A1 Cattel, F
YR 2019
UL http://ejhp.bmj.com/content/26/Suppl_1/A208.1.abstract
AB Background In elderly patients, anticoagulants are the most commonly implicated medication in emergency department (ED) visits due to an adverse drug event (ADE): 17.6% of all ADE requiring the ED are linked to oral anticoagulant: 50% of them require hospital admission.Purpose The aim of the study was to assess whether the main reason for hospitalisation is related to ADE of NOACs: to evaluate the potential exposure to drug-drug interactions/assess whether contraindicated drugs have been prescribed in association with NOACs; and evaluate the economic impact associated with NOACs therapy.Material and methods Data from 2016–2017 were retrieved from administrative and health databases: the File C2 registry which groups all patients admitted to the ED filtered using identified ICD-9-CM codes (International Classification of Diseases) related to ADE possibly induced by anticoagulants; the File F registry, from local health units to identify anticoagulant therapy; and the hospital discharge form (SDO) which stores clinical information about patients. File C2, File F and SDO were matched to estimate costs incurred by the healthcare system: Diagnosis Related Group (DRG) codes were analysed to evaluate the cost/patient.Results Data of 1867 patients were extrapolated from File C2, matched with File F, through ICD9-CM related to ADE from anticoagulants: 43 patients were selected (median age=80 (σ=12), male:76%). The most frequent diagnoses were: subdural haemorrhage (31%), iron deficiency anaemia and chronic blood loss (22%), subarachnoid haemorrhage (9%) due to Warfarin (75.5%), Dabigatran (8.9%), Rivaroxaban (8.9%).Crossing File C2 and SDO, 62% of patients in treatment with anticoagulants underwent hospitalisation (average duration of 10 days) and 22/43 patients showed potential drug-drug interactions mainly due to Warfarin. The average cost per hospitalisation was significantly greater for patients treated with Warfarin versus NOACs (€900 more).The lower economic impact of cases treated with NOACs versus Warfarin per DRG (€56 154 vs €201,743) as for admission to the ED (€1894 vs €6,952) were linked to the minor incidence of serious ADEs.Conclusion Making a simulation, the potential saving would be proportional to the number of hospitalisations avoided, (€29,106,939). Despite the difference in cost of the therapies shifting from AVKs to NOACs, there could be a direct economic saving related to the lower incidence of hospitalization, and indirect from the reduction of ADE.References and/or acknowledgements No conflict of interest.