@article {Vidalejhpharm-2020-002620, author = {Fabrice Vidal and Camille Cotteret and Abdel Negbane and Maria Sebti and M{\'e}lanie Hinterlang and Salvatore Cisternino and Jo{\"e}l Schlatter}, title = {Stability of pemetrexed diarginine concentrates for solution in vials and diluted in 0.9\% sodium chloride and dextrose 5\% polyolefin infusion bags}, elocation-id = {ejhpharm-2020-002620}, year = {2021}, doi = {10.1136/ejhpharm-2020-002620}, publisher = {BMJ Specialist Journals}, abstract = {Objectives To determine the physicochemical stability of pemetrexed diarginine in original vials, and after dilution in two commonly used infusion fluids (0.9\% sodium chloride, 5\% dextrose) in polyolefin bags, stored under refrigeration (2{\textendash}8{\textdegree}C) or at ambient temperature (22{\textendash}25{\textdegree}C) exposed to light.Methods Stability of pemetrexed diarginine injection concentrate was determined in the original glass vials with closed-system transfer device. Diluted pemetrexed diarginine infusion solutions were aseptically prepared by dilution of pemetrexed diarginine concentrate with either 0.9\% sodium chloride or dextrose 5\% in polyolefin bags, in amounts yielding pemetrexed diarginine concentrations of 4, 9 and 12 mg/mL. Test solutions were stored under refrigeration (2{\textendash}8{\textdegree}C) or at ambient temperature (22{\textendash}25{\textdegree}C) exposed to light. Pemetrexed diarginine concentrations were determined throughout a 14-day storage period using a stability-indicating HPLC assay. In addition, test solutions were visually examined for colour change and precipitation.Results Pemetrexed diarginine injection concentrate with closed-system transfer device is shown to be physicochemically stable for up to 4 days when stored under refrigeration and for 1 day at room temperature. A browning of the pemetrexed diarginine concentrate solutions appeared 0n day 2 when stored at ambient temperature and on day 5 under refrigeration. Pemetrexed diarginine diluted in dextrose 5\% and 0.9\% sodium chloride was physicochemically stable for up to 4 days when stored under refrigeration and for 1 day at room temperature. A browning of the diluted solutions appeared on day 2 when stored at room temperature and on day 5 when stored under refrigeration.Conclusions Pemetrexed diarginine concentrate for solution stored under refrigeration with closed-system transfer device can be retained as a residual to reduce product losses. The analytical stability of pemetrexed diarginine in dextrose 5\% and 0.9\% sodium chloride under refrigeration enables our centralised unit to prepare this drug in advance.}, issn = {2047-9956}, URL = {https://ejhp.bmj.com/content/early/2021/03/02/ejhpharm-2020-002620}, eprint = {https://ejhp.bmj.com/content/early/2021/03/02/ejhpharm-2020-002620.full.pdf}, journal = {European Journal of Hospital Pharmacy} }