RT Journal Article
SR Electronic
T1 An update on extravasation: basic knowledge for clinical pharmacists
JF European Journal of Hospital Pharmacy
JO Eur J Hosp Pharm
FD British Medical Journal Publishing Group
SP 165
OP 167
DO 10.1136/ejhpharm-2019-002152
VO 28
IS 3
A1 Smolders, Elise Joelle
A1 Benoist, Guillemette Emma
A1 Smit, Chloe Corrie Hans
A1 ter Horst, Peter
YR 2021
UL http://ejhp.bmj.com/content/28/3/165.abstract
AB Extravasation is the leakage of intravenously administered solution into surrounding tissues, which can cause serious damage to the patient. The impact of extravasation is mostly determined by the localisation and volume of extravasation, but the physicochemical properties of the drugs are also important. In this paper a stepwise approach to managing an extravasation is described, with recommendations on the role of the pharmacist. Information on osmolality, pH, pKa and the buffering capacity of drugs is given in relation to extravasation, which is summarised in a practical crash card that can be used in clinical practice.