RT Journal Article
SR Electronic
T1 Choice of pharmaceutical form as a key factor during ketogenic diet: a case report
JF European Journal of Hospital Pharmacy
JO Eur J Hosp Pharm
FD British Medical Journal Publishing Group
SP ejhpharm-2021-002727
DO 10.1136/ejhpharm-2021-002727
A1 Héctor Rodríguez-Ramallo
A1 Nerea Báez-Gutiérrez
A1 Justo Valverde Fernandez
A1 Francisco José Araujo-Rodríguez
YR 2021
UL http://ejhp.bmj.com/content/early/2021/06/07/ejhpharm-2021-002727.abstract
AB West syndrome is a severe epilepsy syndrome characterised by the appearance of drug-resistant epileptic disorders associated with hypsarrhythmia and intellectual disability. Among non-pharmacological treatments, the ketogenic diet, which consists of low carbohydrate intake and a rich lipid intake, stands out. This treatment induces a state of ketosis, which has been related to a decrease in the number of seizures. It is essential to control the carbohydrate intake within drug treatment for these patients since many pharmaceutical forms, specifically liquid oral medication, may contain carbohydrates in the form of mono/polysaccharides or polyols. We describe the case report of an infant with drug-resistant West syndrome, treated with a ketogenic diet, whose antiseizure liquid medication impeded a proper response to the diet. After the substitution of these medications, the patient showed a remarkable decrease in the number of seizures.All data relevant to the study are included in the article.