TY - JOUR T1 - Piperacillin/tazobactam-induced coagulopathy in a patient through a vitamin K-dependent mechanism JF - European Journal of Hospital Pharmacy JO - Eur J Hosp Pharm SP - 237 LP - 238 DO - 10.1136/ejhpharm-2019-002182 VL - 28 IS - 4 AU - Zhenwei Yu AU - Huadong Chen Y1 - 2021/07/01 UR - http://ejhp.bmj.com/content/28/4/237.abstract N2 - Haematologic side effects associated with piperacillin/tazobactam (PTZ) treatment are rare but can be fatal. The exact mechanism by which PTZ causes haemorrhages has not been determined. We report the case of a patient who received PTZ treatment and developed a coagulopathy through a vitamin K-dependent mechanism. A 70-year-old female patient was admitted to the intensive care unit because she had a severe case of pneumonia and a pulmonary thromboembolism. Empirical antibiotic treatment using PTZ was started. Her international normalised ratio (INR) was already increased and became elevated again when PTZ was restarted. Her coagulopathy was reversed by supplementation with vitamin K. We conclude that PTZ can induce coagulopathy through a vitamin K-dependent mechanism and, to our knowledge, this is the first case report to suggest that mechanism. We suggest that patients at risk for a vitamin K deficiency should be monitored for coagulopathy when piperacillin or any other board spectrum antibiotic is administered.All data relevant to the study are included in the article. ER -