PT  - JOURNAL ARTICLE
AU  - Gascón, Ana
AU  - Castresana, Marta
AU  - Alzueta, Natalia
AU  - Marin, Marta
AU  - Pío, María
AU  - Echeverria, Aitziber
TI  - Combination of ceftaroline and daptomycin as treatment for complicated osteomyelitis
AID  - 10.1136/ejhpharm-2019-002183
DP  - 2021 Sep 01
TA  - European Journal of Hospital Pharmacy
PG  - 289--292
VI  - 28
IP  - 5
4099  - http://ejhp.bmj.com/content/28/5/289.short
4100  - http://ejhp.bmj.com/content/28/5/289.full
SO  - Eur J Hosp Pharm2021 Sep 01; 28
AB  - Osteomyelitis is an infection involving bone. Staphylococcus aureus is the pathogen most frequently implicated; less frequently involved are other gram-positive organisms, such as Staphylococcus epidermidis, and also gram-negative organisms. The antibiotic of choice for treatment of osteomyelitis caused by methicillin-resistant staphylococci (MRS) is vancomycin, although other alternatives such as daptomycin or teicoplanin are also considered. Osteomyelitis caused by MRS can be difficult to treat safely and effectively. This case report describes the successful use of daptomycin combined with ceftaroline for the treatment of osteomyelitis caused by methicillin-resistant S. epidermidis (MRSE) in a 54-year-old woman, emphasising the clinical pharmacist’s role in antimicrobial stewardship programmes. This alternative combination has been studied in the treatment of methicillin-resistant S. aureus (MRSA), but it may also be useful in MRSE.