RT Journal Article
SR Electronic
T1 Combination of ceftaroline and daptomycin as treatment for complicated osteomyelitis
JF European Journal of Hospital Pharmacy
JO Eur J Hosp Pharm
FD British Medical Journal Publishing Group
SP 289
OP 292
DO 10.1136/ejhpharm-2019-002183
VO 28
IS 5
A1 Ana Gascón
A1 Marta Castresana
A1 Natalia Alzueta
A1 Marta Marin
A1 María Pío
A1 Aitziber Echeverria
YR 2021
UL http://ejhp.bmj.com/content/28/5/289.abstract
AB Osteomyelitis is an infection involving bone. Staphylococcus aureus is the pathogen most frequently implicated; less frequently involved are other gram-positive organisms, such as Staphylococcus epidermidis, and also gram-negative organisms. The antibiotic of choice for treatment of osteomyelitis caused by methicillin-resistant staphylococci (MRS) is vancomycin, although other alternatives such as daptomycin or teicoplanin are also considered. Osteomyelitis caused by MRS can be difficult to treat safely and effectively. This case report describes the successful use of daptomycin combined with ceftaroline for the treatment of osteomyelitis caused by methicillin-resistant S. epidermidis (MRSE) in a 54-year-old woman, emphasising the clinical pharmacist’s role in antimicrobial stewardship programmes. This alternative combination has been studied in the treatment of methicillin-resistant S. aureus (MRSA), but it may also be useful in MRSE.