RT Journal Article SR Electronic T1 Baricitinib against severe COVID-19: effectiveness and safety in hospitalised pretreated patients JF European Journal of Hospital Pharmacy JO Eur J Hosp Pharm FD British Medical Journal Publishing Group SP e41 OP e45 DO 10.1136/ejhpharm-2021-002741 VO 29 IS e1 A1 Rubén Iglesias Gómez A1 Raúl Méndez A1 Tomás Palanques-Pastor A1 Octavio Ballesta-López A1 Conxa Borrás Almenar A1 Juan Eduardo Megías Vericat A1 Eduardo López-Briz A1 Isabel Font-Noguera A1 Rosario Menéndez Villanueva A1 José Andrés Román Iborra A1 José Luis Poveda Andrés YR 2022 UL http://ejhp.bmj.com/content/29/e1/e41.abstract AB Objectives To analyse the effectiveness and safety of baricitinib for severe COVID-19 in cytokine storm syndrome based on its potential role as an anti-inflammatory immunomodulator and inhibitor of viral endocytosis.Methods This was an observational retrospective study of hospitalised patients treated with baricitinib for severe COVID-19. Outcomes were clinical improvement on an ordinal scale of 1–8 on day 1 of baricitinib compared with day 14 (where 8=death and 1=not hospitalised with no limitations of activities), overall survival, time to recovery since baricitinib treatment started (days until hospital discharge) and laboratory parameters related to COVID-19 poor prognosis. Adverse events related to baricitinib during the admission period were also reported.Results Forty-three patients (70% men, mean age 70 years (IQR 54–79)) treated with baricitinib daily for 6 days (IQR 5–7) were included. Thirty-six patients were treated with corticosteroids (84%). Clinical improvement was 3 points (IQR 1–4) in patients on an ordinal scale of 4–6, overall survival was 100% at day 30 and day 60 with a mean time to recovery of 12 days (IQR 9–25) from start of baricitinib treatment. No adverse events of interest were found and all poor prognosis risk factors improved at day 14: interleukin-6, C-reactive protein, ferritin, lymphocytes, platelets and D-dimers.Conclusions Patients treated with baricitinib for severe COVID-19 showed improvements in clinical and analytical values without relevant adverse events and 100% overall survival. Clinical randomised trials are needed to confirm the clinical benefit of baricitinib.All data relevant to the study are included in the article or uploaded as supplementary information.