PT - JOURNAL ARTICLE AU - Lijie Xu AU - Xuefang Cheng AU - Guanhua Zhu AU - Juanni Hu AU - Qin Li AU - Guorong Fan TI - Therapeutic drug monitoring of amikacin: quantification in plasma by liquid chromatography-tandem mass spectrometry and work experience of clinical pharmacists AID - 10.1136/ejhpharm-2021-003049 DP - 2022 Mar 01 TA - European Journal of Hospital Pharmacy PG - e77--e82 VI - 29 IP - e1 4099 - http://ejhp.bmj.com/content/29/e1/e77.short 4100 - http://ejhp.bmj.com/content/29/e1/e77.full SO - Eur J Hosp Pharm2022 Mar 01; 29 AB - Objectives As part of the service provided by clinical pharmacists in our hospital, an assay for plasma amikacin quantification by liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been established for clinical use since 2018. This study was undertaken to describe: (1) the establishment of this assay; (2) the application and results of the testing; and (3) the analysis and impact for patients.Methods The amikacin quantification assay was validated and the plasma amikacin concentration data were extracted and analysed. The clinical data for related patients were collected from electronic health and medical records.Results 121 plasma samples from 53 patients were included in this statistical analysis. The use of amikacin was mostly monitored in the intensive care unit and the haematology department, and the monitoring range of amikacin concentrations were about 0.1–57µg/mL. The main indications for amikacin concentration detection were combined medications, impaired renal function, or people over 65 years old, which may increase the incidence of adverse reactions. Amikacin prescribing decisions were diversified due to the combination of assay results and clinical disease progression, and the effective rate of amikacin administration was about 52.8% (28/53).Conclusions The assay for plasma amikacin concentration has been successfully established to monitor the clinical use of amikacin, and the assay results served as one of the references for amikacin prescribing decisions.The data were collected in the database of a third party which were not publicly available due to the patient privacy policy. We have checked it.