PT  - JOURNAL ARTICLE
AU  - Jiawen Lv
AU  - Guannan Wu
AU  - Fang Zhang
AU  - Xin Su
TI  - An unusual case of piperacillin-tazobactam-induced fever, eosinophilia, thrombocytopenia and liver damage
AID  - 10.1136/ejhpharm-2020-002575
DP  - 2022 Mar 01
TA  - European Journal of Hospital Pharmacy
PG  - e91--e94
VI  - 29
IP  - e1
4099  - http://ejhp.bmj.com/content/29/e1/e91.short
4100  - http://ejhp.bmj.com/content/29/e1/e91.full
SO  - Eur J Hosp Pharm2022 Mar 01; 29
AB  - Piperacillin-tazobactam is a broad-spectrum antimicrobial agent that is commonly used in clinical practice. The development of delayed drug hypersensitivity reaction (DHR) has been reported in several cases previously. Here we describe an unusual case of non-immediate DHR due to a prolonged course of piperacillin-tazobactam. We report a 22-year-old man who developed fever, eosinophilia, thrombocytopenia and elevated hepatic enzymes following 17 days of piperacillin-tazobactam for methicillin-sensitive Staphylococcus aureus (MSSA) pneumonia. These adverse reactions were reversed immediately after antibiotic cessation. Our case highlights that clinicians should be aware of delayed adverse effects in patients receiving long-term piperacillin-tazobactam treatment.All data relevant to the study are included in the article.