TY - JOUR T1 - Omega-3 for the prevention of cardiovascular diseases: meta-analysis and trial-sequential analysis JF - European Journal of Hospital Pharmacy JO - Eur J Hosp Pharm SP - 134 LP - 138 DO - 10.1136/ejhpharm-2020-002207 VL - 29 IS - 3 AU - Maria Francesca Cabiddu AU - Alberto Russi AU - Lucia Appolloni AU - Daniele Mengato AU - Marco Chiumente Y1 - 2022/05/01 UR - http://ejhp.bmj.com/content/29/3/134.abstract N2 - Objectives The effectiveness of omega-3 fatty acids (PUFAs) in cardiovascular diseases (CVD) remains a matter of debate. The aim of this work was to evaluate PUFAs in the reduction of cardiovascular mortality in primary and secondary prevention of CVD to determine if further original studies are needed or the available data can be considered conclusive.Methods A meta-analysis was performed according to a dichotomous endpoint followed by a trial-sequential analysis (TSA). Clinical data were identified through a PubMed search based on the following keywords: omega-3 fatty acids; cardiovascular disease; death; and cardiovascular risk. The clinical trials identified by this procedure were subjected to standard meta-analysis and TSA.Results and conclusions A total of 11 randomised studies for 100 609 patients were analysed. Our meta-analysis showed a statistically significant reduction in mortality due to cardiovascular issues (RR=0.937; 95% CI: 0.88 to 0.98; P=0.018). The TSA indicated that no further trials are needed to better evaluate the efficacy of PUFAs in preventing death related to CVD.Data are available upon reasonable request. The data that support the findings of this study are available upon reasonable request. ER -