RT Journal Article
SR Electronic
T1 Omega-3 for the prevention of cardiovascular diseases: meta-analysis and trial-sequential analysis
JF European Journal of Hospital Pharmacy
JO Eur J Hosp Pharm
FD British Medical Journal Publishing Group
SP 134
OP 138
DO 10.1136/ejhpharm-2020-002207
VO 29
IS 3
A1 Maria Francesca Cabiddu
A1 Alberto Russi
A1 Lucia Appolloni
A1 Daniele Mengato
A1 Marco Chiumente
YR 2022
UL http://ejhp.bmj.com/content/29/3/134.abstract
AB Objectives The effectiveness of omega-3 fatty acids (PUFAs) in cardiovascular diseases (CVD) remains a matter of debate. The aim of this work was to evaluate PUFAs in the reduction of cardiovascular mortality in primary and secondary prevention of CVD to determine if further original studies are needed or the available data can be considered conclusive.Methods A meta-analysis was performed according to a dichotomous endpoint followed by a trial-sequential analysis (TSA). Clinical data were identified through a PubMed search based on the following keywords: omega-3 fatty acids; cardiovascular disease; death; and cardiovascular risk. The clinical trials identified by this procedure were subjected to standard meta-analysis and TSA.Results and conclusions A total of 11 randomised studies for 100 609 patients were analysed. Our meta-analysis showed a statistically significant reduction in mortality due to cardiovascular issues (RR=0.937; 95% CI: 0.88 to 0.98; P=0.018). The TSA indicated that no further trials are needed to better evaluate the efficacy of PUFAs in preventing death related to CVD.Data are available upon reasonable request. The data that support the findings of this study are available upon reasonable request.