RT Journal Article
SR Electronic
T1 Therapeutic efficacy of tacrolimus in vernal keratoconjunctivitis: a meta-analysis of randomised controlled trials
JF European Journal of Hospital Pharmacy
JO Eur J Hosp Pharm
FD British Medical Journal Publishing Group
SP 129
OP 133
DO 10.1136/ejhpharm-2020-002447
VO 29
IS 3
A1 Zhao, Min
A1 He, Fazhong
A1 Yang, Yang
A1 Lin, Weijie
A1 Qiu, Wentao
A1 Meng, Qian
A1 Zhang, Jianping
A1 Zhou, Zhiling
YR 2022
UL http://ejhp.bmj.com/content/29/3/129.abstract
AB Background and objective Tacrolimus has been widely used in recent years for treating allergic conjunctivitis, but there is currently no available meta-analysis regarding its therapeutic efficacy. This study systematically evaluated the effectiveness of tacrolimus in the treatment of allergic conjunctivitis.Methods Data obtained from literature searches of the PubMed, Cochrane Library, Embase, CNKI, and Wanfang databases were retrieved by combining medical subject words and free words. Literature was selected on the basis of established inclusion and exclusion criteria, and the extracted data were evaluated for risk of bias using RevMan 5.3 for meta-analysis.Results A total of 177 articles were retrieved, of which 5 articles were eventually selected, all of which involved tacrolimus treatment for vernal keratoconjunctivitis. A total of 203 samples were analysed. Results of the meta-analysis showed that the tacrolimus treatment group had significantly lower ocular objective sign scores (SMD −1.39, 95% CI −2.50 to −0.27; p<0.05) and had a significantly lower subjective symptom evaluation score (SMD −0.92, 95% CI −1.59 to −0.24; p<0.05) than the control group.Conclusion Current evidence shows that tacrolimus is effective in treating vernal keratoconjunctivitis.Data is available in a public, open access repository. Data comes from PubMed, Cochrane Library, Embase, CNKI, and Wanfang databases.