PT  - JOURNAL ARTICLE
AU  - Sixtine Gilliot
AU  - Anthony Martin Mena
AU  - Stéphanie Genay
AU  - Morgane Masse
AU  - Manon Thibaut
AU  - Natacha Carta
AU  - Damien Lannoy
AU  - Laura Négrier
AU  - Christine Barthélémy
AU  - Bertrand Décaudin
AU  - Pascal Odou
TI  - Factors influencing accuracy when preparing injectable drug concentrations in appliance with clinical practice: a norepinephrine case study
AID  - 10.1136/ejhpharm-2022-003358
DP  - 2022 Jul 26
TA  - European Journal of Hospital Pharmacy
PG  - ejhpharm-2022-003358
4099  - http://ejhp.bmj.com/content/early/2022/07/26/ejhpharm-2022-003358.short
4100  - http://ejhp.bmj.com/content/early/2022/07/26/ejhpharm-2022-003358.full
AB  - Errors in injectable preparations with high-risk drugs can be fatal. This study aimed to identify the factors influencing the accuracy of high-risk injectable drug concentrations in appliances used for intensive care unit preparation practices. Norepinephrine (NE) was chosen as an example of a high-risk medication drug. The concentration (0.2 and 0.5 mg/mL), the diluent (sodium chloride 0.9% and 5% dextrose), and the container type (prefilled- and empty-infusion bag and syringe) were tested as potential variability factors. An ultraviolet spectrophotometric method was used for NE dosage. 108 NE solutions were prepared by five individuals (pharmacists or laboratory technicians) with clinical experience as well as experience in the aseptic preparation of solutions. The container type was found to be the only factor influencing the accuracy of NE concentration. NE solutions in syringes proved to be the most accurate while preparations in prefilled bags tended to underdose NE.No data are available.