PT - JOURNAL ARTICLE AU - Kagami, Keisuke AU - Ishiguro, Nobuhisa AU - Iwasaki, Sumio AU - Taki, Keisuke AU - Fukumoto, Tatsuya AU - Hayasaka, Kasumi AU - Oyamada, Reiko AU - Watanabe, Tsubasa AU - Nakakubo, Sho AU - Niinuma, Yusuke AU - Sugawara, Mitsuru AU - Takekuma, Yoh TI - Correlation between antibiotic use and resistance of gram-negative bacteria at a university hospital in Japan from 2013 to 2021: a study using the Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system AID - 10.1136/ejhpharm-2023-003797 DP - 2023 Jul 12 TA - European Journal of Hospital Pharmacy PG - ejhpharm-2023-003797 4099 - http://ejhp.bmj.com/content/early/2023/07/17/ejhpharm-2023-003797.short 4100 - http://ejhp.bmj.com/content/early/2023/07/17/ejhpharm-2023-003797.full AB - Objectives The Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system aggregates information related to antimicrobial resistance (AMR) measures. We aimed to investigate the correlation between antibiotic use and AMR at a university hospital from 2013 to 2021 in a time series analysis using the J-SIPHE system. We also studied this correlation in each ward (inter-ward analysis).Methods Data on antibiotic use and resistance rates were collected from the J-SIPHE system, except for the resistance rate in each ward, which was calculated from the source data prepared for this system.Results Piperacillin/tazobactam use was positively correlated with piperacillin/tazobactam resistance in Escherichia coli and Klebsiella pneumoniae in the inter-ward analysis, and in Pseudomonas aeruginosa in both analyses. Carbapenem use was positively correlated with meropenem resistance in Enterobacter cloacae in the time series analysis and in P. aeruginosa in both analyses, and imipenem/cilastatin resistance in P. aeruginosa in inter-ward analysis. Quinolone use was positively correlated with levofloxacin resistance in E. coli in both analyses, and in K. pneumoniae in inter-ward analysis.Conclusions This is the first study to investigate the correlation between antibiotic use and AMR at a single hospital in time series and inter-ward analyses using the J-SIPHE system and data prepared for this system, suggesting that this system may be useful for promoting AMR measures.No data are available.