RT Journal Article
SR Electronic
T1 Correlation between antibiotic use and resistance of gram-negative bacteria at a university hospital in Japan from 2013 to 2021: a study using the Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system
JF European Journal of Hospital Pharmacy
JO Eur J Hosp Pharm
FD British Medical Journal Publishing Group
SP ejhpharm-2023-003797
DO 10.1136/ejhpharm-2023-003797
A1 Kagami, Keisuke
A1 Ishiguro, Nobuhisa
A1 Iwasaki, Sumio
A1 Taki, Keisuke
A1 Fukumoto, Tatsuya
A1 Hayasaka, Kasumi
A1 Oyamada, Reiko
A1 Watanabe, Tsubasa
A1 Nakakubo, Sho
A1 Niinuma, Yusuke
A1 Sugawara, Mitsuru
A1 Takekuma, Yoh
YR 2023
UL http://ejhp.bmj.com/content/early/2023/07/17/ejhpharm-2023-003797.abstract
AB Objectives The Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system aggregates information related to antimicrobial resistance (AMR) measures. We aimed to investigate the correlation between antibiotic use and AMR at a university hospital from 2013 to 2021 in a time series analysis using the J-SIPHE system. We also studied this correlation in each ward (inter-ward analysis).Methods Data on antibiotic use and resistance rates were collected from the J-SIPHE system, except for the resistance rate in each ward, which was calculated from the source data prepared for this system.Results Piperacillin/tazobactam use was positively correlated with piperacillin/tazobactam resistance in Escherichia coli and Klebsiella pneumoniae in the inter-ward analysis, and in Pseudomonas aeruginosa in both analyses. Carbapenem use was positively correlated with meropenem resistance in Enterobacter cloacae in the time series analysis and in P. aeruginosa in both analyses, and imipenem/cilastatin resistance in P. aeruginosa in inter-ward analysis. Quinolone use was positively correlated with levofloxacin resistance in E. coli in both analyses, and in K. pneumoniae in inter-ward analysis.Conclusions This is the first study to investigate the correlation between antibiotic use and AMR at a single hospital in time series and inter-ward analyses using the J-SIPHE system and data prepared for this system, suggesting that this system may be useful for promoting AMR measures.No data are available.