Table 1

Recommended initial doses for morphine in opioid-naïve neonates and infants

Age group	Route of administration	Recommended starting dose
Neonates	Intravenous injection*	25–50 μg/kg every 6 h
	Subcutaneous injection	25–50 μg/kg every 6 h
	Intravenous infusion	Initial intravenous dose* 25–50 μg/kg, then 5–10 μg/kg/h
Infants (1 month to 1 year)	Oral (immediate release)	80–200 μg/kg every 4 h
	Intravenous injection*	1–6 months: 100 μg/kg every 6 h 6–12 months: 100 μg/kg every 4 h (max 2.5 mg/dose)
	Subcutaneous injection
	Intravenous infusion*	1–6 months: initial intravenous dose: 50 μg/kg, then: 10–30 μg/kg/h 6–12 months: initial intravenous dose: 100–200 μg/kg, then: 20–30 μg/kg/h
	Subcutaneous infusion	1–3 months: 10 μg/kg/h 3–12 months: 20 μg/kg/h