Criteria for toxicity evaluation (see reference 16 for meaning of R/S phrases)
| Carcinogenicity | Mutagenicity | Reproductive and developmental toxicity | Irritating potential | |
|---|---|---|---|---|
| Risk phrases | R45, R49 | R46 | R60, R61, R62, R63 | Skin: R21, R24, R27, R34, R35, R38, R43 |
| Eyes: R36, R41 | ||||
| Respiratory tract: R20, R23, R26, R37, R42 | ||||
| Security phrases | Skin: S24, S28, S37 | |||
| Eyes: S25, S26, S39 | ||||
| Respiratory tract: S22, S23, S38, S51 | ||||
| Swiss SPC | Preclinical data | Preclinical data | Pregnancy data | Chapter ‘Remarks’ |
| Preclinical data | ||||
| Other | IARC classification in groups 1, 2A and 2B (group 3: should be discuss individually) | FDA pregnancy categories X, D (category C: wear protective measures) |
IARC, International Agency for Research on Cancer; SPC, summary of product characteristics.