Table 5

Results of the high performance liquid chromatography determinations of drug concentrations in the sufentanil–human insulin–midazolam combination. For technical reasons, some assay results for insulin and sufentanil at T2, T4 and T6 are not available.

	% of expected concentration
	Dynamic simulation					Test tube
Active drug	Calculated flow rate	2 h	4 h	6 h	24 h	0 h	24 h	Relative difference (%)
Sufentanil	1.06 ml/h	98.8	106.0	107.0	101.4	103.4	103.3	−0.06
Midazolam	1.02 ml/h	33.4	99.0	99.0	98.9	107.8	108.7	0.80
Insulin	1.03 ml/h	–	–	–	–	104.0	102.6	−1.36
Maintenance infusion	1.07 ml/h
Sufentanil	1.07 ml/h	106.1	102.6	106.8		100.2	100.3	0.10
Midazolam	1.02 ml/h	74.1	96.4	97.8		95.6	94.3	−1.37
Insulin	4.15 ml/h	106.9	106.8	106.8		99.5	99.2	−0.30
Maintenance infusion	1.01 ml/h
Sufentanil	1.05 ml/h	–	–	–		106.6	105.2	−1.34
Midazolam	4.08 ml/h	101.8	97.3	95.0		92.4	93.2	0.87
Insulin	1.00 ml/h	–	–	–		103.5	105.7	2.10
Maintenance infusion	1.07 ml/h
Sufentanil	1.05 ml/h	–	–	–		108.1	107.9	−0.19
Midazolam	4.13 ml/h	98.5	100.2	99.9		92.8	94.2	1.54
Insulin	4.17 ml/h	–	–	–		97.8	98.1	0.31
Maintenance infusion	1.08 ml/h
Sufentanil	4.15 ml/h	106.9	101.6	108.2		107.0	107.6	0.56
Midazolam	1.03 ml/h	100.9	99.4	103.9		99.4	100.6	1.20
Insulin	0.99 ml/h	–	–	–		99.8	99.0	−0.80
Maintenance infusion	1.09 ml/h
Sufentanil	4.14 ml/h	103.8	103.1	103.4		103.2	103.5	0.29
Midazolam	1.09 ml/h	97.0	101.7	100.5		100.3	98.3	−1.97
Insulin	4.29 ml/h	102.0	102.0	102.0		100.2	99.3	−0.90
Maintenance infusion	1.10 ml/h
Sufentanil	4.12 ml/h	–	–	–		106.4	107.3	0.84
Midazolam	4.11 ml/h	105.8	104.5	104.5		97.4	98.4	1.08
Insulin	1.12 ml/h	–	–	–		103.3	101.7	−1.56
Maintenance infusion	1.00 ml/h