Table 1

Results of the visual compatibility tests between remifentanil hydrochloride and various drugs

Remifentanil hydrochloride 0.12 mg/ml in D5WPropofol 20 mg/mlC
Midazolam 1 mg/ml in D5WC
Furosemide 1 mg/ml in NSIC*
Heparin sodium 416.7 U/ml in NSC
Monobasic potassium phosphate 1 mmol/mlC
Insulin 1 U/ml in D5WC
Propofol 20 mg/mlC
Midazolam 1 mg/ml in D5WC
Magnesium sulfate/GS 8 mg/ml in GSC
Insulin 1 U/ml in D5WC
Propofol 20 mg/mlC
Midazolam 1 mg/ml in D5WC
Furosemide 1 mg/ml in NSIC
Heparin sodium 416.7 U/ml in NSC
Magnesium sulfate/RLS 8 mg/ml in RLSC
Insulin 1 U/ml in D5WC
Propofol 20 mg/mlC
Midazolam 1 mg/ml in D5WC
Furosemide 1 mg/ml in NSC
Heparin sodium 416.7 U/ml in NSC
Potassium chloride 1 mmol/mlC
Insulin 1 U/ml in D5WC
Propofol 20 mg/mlC
Midazolam 1 mg/ml in D5WC
Furosemide 1 mg/ml in NSIC
Heparin sodium 416.7 U/ml in NSC
Magnesium sulfate/GS 8 mg/ml in GSInsulin 1 U/ml in D5WC
Propofol 20 mg/mlC
Midazolam 1 mg/ml in D5WC
Furosemide 1 mg/ml in NSIC§
Heparin sodium 416.7 U/ml in NSC
Magnesium sulfate/RLS 8 mg/ml in RLSInsulin 1 U/ml in D5WC
Propofol 20 mg/mlC
Midazolam 1 mg/ml in D5WC
Furosemide 1 mg/ml in NSC
Heparin sodium 416.7 U/ml in NSC
  • * Remifentanil–furosemide: a white precipitate appeared in the 1:1 (with or without agitation), 1:4 and 4:1 solutions after 15, 30 and 120 min, respectively.

  • Remifentanil–MgSO4/GS–furosemide: a white precipitate appeared in all solutions, after 15 min (1:1:1 and 4:1:4), 60 min (4:1:1), 24 h (1:1:4, 4:4:1) or more (1:4:1, 1:4:4).

  • Remifentanil–KCl–furosemide: a white precipitate appeared in the 4:1:4, 1:1:1, 4:1:1 and 4:4:1 solutions after 15, 60, 120 min and 24 h respectively. The other solutions remained clear.

  • § Remifentanil–KCl–MgSO4/GS–furosemide: a white precipitate appeared after 15 min (4:4:1:1, 4:1:1:4 solutions), 30 min (1:1:1:1, 4:1:1:1, 4:1:4:4, 4:4:1:4 solutions) and 24 h (4:1:4:1 solution). The other solutions remained clear, but the 1:1:4:4, 1:4:4:1 and 4:4:4:1 solutions showed a lot of little bubbles.

  • C, compatible; D5W, dextrose 5%; GS, Glucosaline (3.3% dextrose and 0.3% NaCl); IC, incompatible; NS, NaCl 0.9%; RLS, Ringer lactate stocker.