Table 2

 Unitary costs and adverse event management costs (euros, 2011)

Unitary costsCost
Drug costs*22
 Trabectedin (Yondelis) 1 mg, 1 vial1994
 Trabectedin (Yondelis) 250 ∝g, 1 vial530
 PLD (Caelyx, Janssen-Cilag International,   Belgium) 20 mg, 1 vial369.86
Resources21
 Day care hospital (by session)203.88
 CT scan135.18
 Vascular access for catheter installation634.32
 Specialist visit41.53
 End-of-life phase6050.9
Adverse eventsGrade 3Grade 4
 Anaemia19419.94698.70
 Diarrhoea19623.191369.38
 Nausea/vomiting19458.961440.42
 Febrile neutropenia202238.392238.39
 Neutropenic infection3729.11†3729.11†
 Neutropenic sepsis193729.113729.11
 Neutropenia19192.57527.07
 Palmar-plantar erythrodysaesthesia  syndrome19216.681333.33
 Thrombocytopenia19249.90729.69
 Stomatitis19932.371712.39

  • *Ex-factory prices per package.

  • †Assumed as neutropenic sepsis.