Adverse event10 | Trabectedin plus PLD | PLD | ||
---|---|---|---|---|
Grade 3 (%) | Grade 4 (%) | Grade 3 (%) | Grade 4 (%) | |
Anaemia | 13.8 | 4.1 | 4.9 | 2.0 |
Diarrhoea | 2.8 | 0.0 | 1.9 | 0.0 |
Nausea/vomiting | 14.3 | 0.5 | 1.9 | 0.0 |
Febrile neutropenia | 4.1 | 1.8 | 1.4 | 0.5 |
Neutropenic infection | 0.5 | 0.0 | 0.0 | 0.0 |
Neutropenic sepsis | 0.5 | 0.0 | 0.0 | 0.0 |
Neutropenia | 31.8 | 41.0 | 20.0 | 11.2 |
Palmar-plantar erythrodysaesthesia syndrome | 3.7 | 0.0 | 20.2 | 0.5 |
Thrombocytopenia | 11.5 | 9.7 | 2.4 | 2.4 |
Stomatitis | 1.4 | 0.0 | 4.3 | 0.0 |
PLD, pegylated liposomal doxorubicin.