Drug selection | C1.1 | Inappropriate drug | 80 | 17.6 | 68.8 | Diazepam in a 85-year-old patient for insomnia |
C1.2 | No indication for drug | 84 | 18.5 | 88.1 | Omeprazole in a 84-year-old patient with no indication of gastroprotection |
C1.3 | Inappropriate combination of drugs, or drugs and food | 2 | 0.4 | 50.0 | Calcium plus ciprofloxacin |
C1.4 | Inappropriate duplication of therapeutic drug or active ingredient | 28 | 6.2 | 100.0 | Lorazepam plus lormetazepam in a 82-year-old patient at dinner and before sleep |
C1.5 | Indication of drug treatment not noticed | 85 | 18.7 | 95.3 | Antipsychotics without indication |
C1.6 | Too many drugs prescribed for indication | 1 | 0.2 | 0.0 | Sertraline plus trazodone plus mirtazapine for same indication |
C1.7 | More cost-effective drug available | 16 | 3.5 | 87.5 | Rabeprazole versus omeprazole |
C1.8 | Synergistic/preventive drug required and not given | 41 | 9.0 | 53.7 | Lung oedema and no diuretic |
C1.9 | New indication for drug treatment presented | 46 | 10.1 | 69.6 | Iron-deficiency anaemia without treatment |
Dose selection | C3.1 | Drug dose too low | 2 | 0.4 | 100.0 | Betahistine 8 mg/24 h for treatment of Meniere's syndrome |
C3.2 | Drug dose too high | 10 | 2.2 | 90.0 | Digoxin 0.25 μg/24 h 7 days a week in impaired renal function |
C3.4 | Dosage regimen too frequent | 1 | 0.2 | 100.0 | Potassium supplements in a low-dose furosemide |
C3.6 | Pharmacokinetic problem requiring dose adjustment | 11 | 2.4 | 100.0 | Acetaminophen 1 g/6 h in a patient with renal impairment |
C3.7 | Deterioration/improvement of disease state requiring dose adjustment | 6 | 1.3 | 83.3 | Simvastatin and low cholesterol level |
Treatment duration | C4.2 | Duration of treatment too long | 8 | 1.8 | 62.5 | Antihistaminic chronic use |
Drug use process | C5.1 | Inappropriate timing of administration and/or dosing | 3 | 0.7 | 100.0 | Darunavir, ritonavir and etravirine administrated with calcium |