Recommendations using the CG formula compared with those that would have been made using the MDRD4 formula
| Drug | Recommendation with GFR calculated by CG | Recommendation with GFR calculated by MDRD4 | n |
|---|---|---|---|
| 200 mg/24 h | 300 mg/24 h | 3 | |
| Allopurinol | 150 mg/24 h | 200 mg/24 h | 14 |
| 100 mg/48 h | 150 mg/24 h | 2 | |
| Amoxycillin/clavulanic | 500/12 h | UD | 8 |
| Amikacin* | 7.5 mg/kg/24 h | 5 mg/kg/24 h | 1 |
| Ampicillin | 1–2 g/8 h | 1–2 g/6 h | 2 |
| Captopril | 12.5 mg/8 h | UD | 1 |
| Ceftriaxone | 1 g/24 h | UD | 1 |
| Ciprofloxacin | 200 mg/12 h | UD | 2 |
| Colchicine | Avoid | 0.5 mg/24 h | 1 |
| Di: 5–10 mg/24 h | 2.5–20 mg/24 h | 10 | |
| Enalapril | Di: 2.5 mg/24 h | Di: 5–10 mg/24 h | 6 |
| Di: 2.5 mg/24 h | 2.5–20 mg/24 h | 1 | |
| Fenofibrate | 160 mg/24 h | 145–250 mg/24 h | 1 |
| Gentamicin* | 4–5 mg/kg/48 h | 3.5 mg/kg/24 h | 1 |
| Hydrochlorothiazide | Avoid | UD | 6 |
| Levofloxacin | 250 mg/24 h | 500 mg/24 h | 14 |
| 250 mg/48 h | 250 mg/24 h | 3 | |
| 0.5–1 g/8 h | 0.5–1 g/6–8 h | 5 | |
| Meropenem | 0.5–1 g/12 h | 0.5–1 g/8 h | 8 |
| 0.5–1 g/24 h | 0.5–1 g/12 h | 1 | |
| Piperacillin-Tazobactam | 3 g/8 h | 2–4/6–8 h | 5 |
| 2 g/8 h | 3 g/8 h | 2 | |
| Ramipril | 2.5–5 mg/24 h | 5–10 mg/24 h | 5 |
| 1.25–5 mg/24 h | 2.5–5 mg/24 h | 17 | |
| Ranitidine | 50 mg/8 h | 50 mg/6–8 h | 10 |
| 50 mg/12 h | 50 mg/8 h | 10 | |
| Teicoplanin | 200 mg/24 h | 400 mg/24 h | 2 |
| Tobramycin* | 3.5 mg/kg/24 h | 4–5 mg/kg/24 h | 1 |
| Vancomycin* | 1 g/24 h | 15–20 mg/kg/24 h | 1 |
| 1 g/72 h | 1 g/24 h | 1 |
*Monitoring of plasma levels recommended.
CG, Cockcroft–Gault; Di, initial dose; GFR, glomerular filtration rate; MDRD4, modified diet in renal disease; UD, usual dose.