| N | 28 |
|---|---|
| Sex (males) | 18 (64.3) |
| Age (years) | 76.5 (72–80) |
| Weight (kg) | 75 (63.3–85.5) |
| BMI (kg/m2) | 27.4 (24.8–32.1) |
| Adjusted weight (kg) | 69.2 (60.8–75.1) |
| SOFA score | 4 (3–6) |
| Sepsis (n) | 20 (71.4) |
| Septic shock (n) | 3 (10.7) |
| Dosage (mg/kg/24 hour) | 21.5 (20–25) |
| Supratherapeutic peak (>50 mcg/ml) (n) | 21 (75) |
| Supratherapeutic trough (>1 mcg/ml) (n) | 22 (78.6) |
| SCr (initial) (mg/dL) | 0.76 (0.65–0.85) |
| SCr (worst) (mg/dL) | 1.1 (0.87–1.23) |
| GFR (initial) (ml/min) | 88 (77.9–90.1) |
| GFR (worst) (ml/min) | 59 (46–72.8) |
| RIFLE (SCr) (no damage-risk-injury-failure) | 17 (60.7)–6 (21.4)–3 (10.7)–2 (7.1) |
| RIFLE (GFR) (no damage-risk-injury-failure) | 13 (46.4)–11 (39.4)–2 (7.1)–2 (7.1) |
| Day worst SCr/GFR value (n) | 2 (1–4.3) |
| Interval | Increase (n): 20 (71.4) Maintain (n): 5 (17.9) Reduce (n): 1 (3.6) Stop (n): 2 (7.1) |
| Dose | Reduce (n): 19 (67.9) Maintain (n): 6 (21.4) Increase (n): 1 (3.6) Stop (n): 2 (7.1) |