Stability of furosemide in formulations F1 and F2 stored at 25°C and at 40°C*
Time (days) | 25°C±3°C | 40°C±0.5°C | ||
F1 | F2 | F1 | F2 | |
0 (100%) | 2.15±0.02 mg/mL | 2.12±0.05 mg/mL | 2.15±0.02 mg/mL | 2.12±0.05 mg/mL |
7 | 102.33±1.39 | 98.14±2.10 | 99.06±2.35 | 92.89±2.62 |
30 | 98.60±1.30 | 97.67±0.12 | 100.00±1.50 | 94.34±1.77 |
90 | 98.14±1.48 | 96.28±0.78 | 98.58±0.99 | 94.81±1.27 |
180 | 99.07±0.61 | 91.63±0.66 | 100.00±0.61 | 95.75±1.05 |
270 | 93.95±0.56 | 92.56±1.05 | 95.28±2.33 | 91.98±0.50 |
*Mean ± SD of determinations for four samples (n=4).