Table 2

The percentage of intravenous co-trimoxazole remaining in the glucose 5% infusion stored at room temperature for various time points. Results are expressed as mean±SD. Each intravenous co-trimoxazole infusion bag was prepared in triplicate and each sample analysed in duplicate

Dilution ratioDrugInitial concentration% Initial drug concentration remaining
0 hour (mg/mL)0.5 hour1 hour2 hours4 hours
 1:25 v/vTrimethoprim0.63101±0.8100±0.6100±1.0100±1.5
Sulfamethoxazole3.18100±6.2100±2.2100±4.5100±6.3
 1:20 v/vTrimethoprim0.8100±0.8100±0.499±0.599±1.2
Sulfamethoxazole3.99100±2.8100±1.9100±2.299±6.3
 1:15 v/vTrimethoprim1.0699±0.599±0.499±0.598±0.4
Sulfamethoxazole5.2999±2.2100±4.799±2.698±2.8
 1:10 v/vTrimethoprim1.64100±0.599±1.0100±1.6100±0.7
Sulfamethoxazole8.12100±2.799±5.2100±5.9100±4.7