Median | IQR | Min | Max | |
Vancomycin continuous (n=56) | ||||
Vd (L) | 47.0 | 41.3–52.9 | 16.2 | 74.4 |
Vd (L/kg) | 0.59 | 0.50–0.71 | 0.27 | 0.91 |
Cl (L/h) | 2.20 | 1.34–2.84 | 0.80 | 8.02 |
Cl (L/h/kg) | 0.025 | 0.018–0.039 | 0.009 | 0.092 |
T1/2 (h) | 15.4 | 11.1–23.2 | 4.7 | 37.4 |
Vancomycin intermittent (n=45) | ||||
Vd (L) | 54.2 | 45.4–63.3 | 19.8 | 100.7 |
Vd (L/kg) | 0.66 | 0.52–0.81 | 0.08 | 0.98 |
Cl (L/h) | 2.73 | 1.79–4.23 | 0.37 | 7.12 |
Cl (L/h/kg) | 0.033 | 0.022–0.051 | 0.007 | 0.119 |
T1/2 (h) | 14.5 | 8.8–21.1 | 5.0 | 59.9 |
Amikacin (n=37) | ||||
Vd (L) | 19.6 | 17.5–21.4 | 9.5 | 26.9 |
Vd (L/kg) | 0.26 | 0.23–0.27 | 0.18 | 0.32 |
Cl (L/h) | 1.50 | 0.97–2.52 | 0.21 | 7.51 |
Cl (L/h/kg) | 0.022 | 0.013–0.036 | 0.004 | 0.063 |
T1/2 (h) | 9.0 | 4.6–12.4 | 2.4 | 58.2 |
Gentamicin (n=14) | ||||
Vd (L) | 15.5 | 13.9–20.0 | 11.0 | 23.7 |
Vd (L/kg) | 0.21 | 0.19–0.22 | 0.09 | 0.29 |
Cl (L/h) | 1.95 | 1.39–3.03 | 0.53 | 3.47 |
Cl (L/h/kg) | 0.028 | 0.014–0.040 | 0.006 | 0.058 |
T1/2 (h) | 5.2 | 4.3–8.5 | 2.7 | 21.4 |
Cl, clearance; T1/2, half-life; Vd, volume of distribution.