Table 2

Pharmacokinetic data (based on two measured drug serum concentrations)

Median IQR Min Max
Vancomycin continuous (n=56)
 Vd (L)47.041.3–52.916.274.4
 Vd (L/kg)0.590.50–0.710.270.91
 Cl (L/h)2.201.34–2.840.808.02
 Cl (L/h/kg)0.0250.018–0.0390.0090.092
 T1/2 (h)15.411.1–23.24.737.4
Vancomycin intermittent (n=45)
 Vd (L)54.245.4–63.319.8100.7
 Vd (L/kg)0.660.52–0.810.080.98
 Cl (L/h)2.731.79–4.230.377.12
 Cl (L/h/kg)0.0330.022–0.0510.0070.119
 T1/2 (h)14.58.8–21.15.059.9
Amikacin (n=37)
 Vd (L)19.617.5–21.49.526.9
 Vd (L/kg)0.260.23–0.270.180.32
 Cl (L/h)1.500.97–2.520.217.51
 Cl (L/h/kg)0.0220.013–0.0360.0040.063
 T1/2 (h)9.04.6–12.42.458.2
Gentamicin (n=14)
 Vd (L)15.513.9–20.011.023.7
 Vd (L/kg)0.210.19–0.220.090.29
 Cl (L/h)1.951.39–3.030.533.47
 Cl (L/h/kg)0.0280.014–0.0400.0060.058
 T1/2 (h)5.24.3–8.52.721.4
  • Cl, clearance; T1/2, half-life; Vd, volume of distribution.