Characteristics of the four aspirin tablets included in the study
| Dispersible Aspirin (Aspar) | Bayer Chewable (Bayer) | Disprin (Reckitt Benckiser) | Aspirin (Bayer) | |
| Weight (g)* | 0.150±0.003 | 0.228±0.002 | 0.473±0.003 | 0.597±0.003 |
| Dimensions, diameter × height (mm)† | 7.03×2.90 | 8.00×4.25 | 12.80×2.70 | 12.06×4.90 |
| pH of dispersed tablet‡ | 4.60 | 3.02 | 4.96 | 2.84 |
| Friability (%)§ | 0.44 (n=42) | 0.07 (n=29) | 0.84 (n=14) | 0.11 (n=11) |
| Disintegration time (s)¶ | 31 (25–38) | 34 (26–40) | 30 (23–35) | 6 (5–10) |
| Tensile strength (N/mm2)** | 1.45 (1.26–1.62) | 1.58 (1.21–1.78) | 1.22 (1.03–1.36) | 0.87 (0.78–0.93) |
*Mean (g)±SD (n=8).
†Mean, n=3; SD% <1.5%.
‡pH of one tablet suspended in 10 mL purified water (n=1); pH of purified water: 6.28±0.61 (average±SD) (n=7).
§Per cent lost on friability testing (PhEur 9.2) (n, according to PhEur).
¶Average time (s) to disintegrate (n=6) (low–high).
**Calculated from breaking strength (N), diameter (mm) and height (mm). Average values are given (n=10) (low–high).
PhEur, European Pharmacopoeia.