Table 3

Most frequently used compounded drugs across paediatric hospitals in the Netherlands

DrugTherapeutic class according to EMA needs for paediatric medicinesFormulation requirement according to EMA needs for paediatric medicines
AcetazolamideNeurologyNo
AmlodipineNephro-urologyYes
CaffeineRespiratoryNo
CarvedilolCardiovascularYes
Chloral hydrateNeurology/PsychiatryYes
ClobazamNeurologyNo
ClonidineCardiovascularYes
DexamethasoneEndocrinologyNo
EnalaprilNephro-urologyYes
FurosemideNephro-urologyNo
HydrochlorothiazideNephro-urologyYes
HydrocortisoneEndocrinology/ImmunologyYes
LabetalolCardiovascularNo
LorazepamNeurology/PsychiatryYes
MethadonePainNo
MidazolamAnaesthesiology/PsychiatryYes
NifedipineNephro-urologyYes
PancreatineGastroenterologyYes
PhenobarbitalNeurologyYes
PhenytoinNeurologyNo
PrednisoloneRheumatology/ImmunologyYes
PropranololCardiovascularNo
SildenafilCardiovascularNo
Sodium benzoateMetabolic disordersNo
Sotalol (hydrochloride)CardiovascularYes
SpironolactoneNephro-urologyNo
TacrolimusImmunologyNo
TopiramateNeurology/PsychiatryYes
  • EMA, European Medicines Agency.