Experimental conditions verifying stability of selected cephalosporins
| Cephalosporins Authors | Studied (C) | Dose in 240 mL | Diluent | Conditions under which >90% stability is confirmed | |
| Cefepime | |||||
| Baririan, N, et al 41 | 12% w/v | 28.8 g | SWFI | 16 hours at 25°C | |
| Rabouan-Guyon, S M, et al 42 | 8 mg/mL | 1.92 g | NS | 3 days at 24°C | |
| 8 mg/mL | 1.92 g | 5D | 2 days at 24°C | ||
| Sprauten, P F, et al 19 | 6 g/250 mL | 5.76 g | 5D | SEQ 7 days at 4°C, then 24 hours at 'room temp' (max 29) | |
| Stewart, J T, et al 18 | 100 mg/mL | 24 g | NS, SWFI | SEQ 7 days at 4°C, then 1 day at 22–24°C | |
| 200 mg/mL | 48 g | 5D, SWFI | SEQ 7 days at 4°C, then 1 day at 22–24°C | ||
| Trissel, L A and Q A Xu43 | 1 g/100 mL | 2.4 g | NS | 2 days at 23°C | |
| 4 g/100 mL | 9.6 g | NS | 1 day at 23°C | ||
| Viaene, E, et al 20 | 50 g/L | 12 g | SWFI | 20.5 hours at 25°C and 13 hours at 37°C | |
| Voumard, R, et al 40 | 12.5 g/L | 3g | NS | 24 hours at room temperature | |
| Cefotaxime | |||||
| Behin,S, et al 44 | 100 mg/mL | 24 g | SWFI | 24 hours at 25°C | |
| Das Gupta, V, et al 45 | 1 g/100 mL | 2.4 g | NS, 5D | 1 day at 24°C | |
| Das Gupta, V 46 | 1% w/v | 2.4 g | NS, 5D | 1 day at 24°C | |
| Das Gupta, V 47 | 50 mg/mL | 12 g | NS | 1 day at 25°C | |
| Cefoxitin | |||||
| Borst, D L, et al 48 | 1–2g/10 mL | 24–48g | SWFI | 2 days at 24°C | |
| Stiles, M L, et al 21 | 40 mg/mL | 9.6 g | SWFI | SEQ 30 days at −20°C, then 4 days at 5°C, then 1 day at 37°C | |
| Ceftazidime | Pyridine | ||||
| Allen Jr, L V, et al 4 | 20 mg/mL | 4.8 g | NS, D5 | 18 hours at 25°C | Not Recorded |
| Arsène, M, et al 49 | 40 mg/mL | 9.6 g | NS | 20 hours at 20°C (in PVC/PP) | Recorded |
| 40 mg/mL | 9.6 g | 5D | 20 hours at 20°C (in PP) | ||
| Baririan, N, et al 41 | 12% w/v | 28.8 g | SWFI | 24 hours at 25°C, and 16 hours at 30°C | Not Recorded |
| Bednar, D A, et al 22 | 60 mg/mL | 14.4 g | NS | 24 hours at 27°C, SEQ (48 hours at 4°C then 20 hours at 27°C), (6 days at 4°C then 24 hours at 27°C) | Not Recorded |
| 120 mg/mL | 28.8 g | NS | 16 hours at 27°C, SEQ (6 days at 4°C then 16 hours at 27°C) | ||
| Das Gupta, V, et al 50 | 4 g/100 mL | 9.6 g | NS,5D | 2 days at 25°C | Not Recorded |
| Farina, A, et al 51 | 270 mg/mL | 64.8 g | SWFI | 24 hours at 20°C | Recorded |
| Nahata, M C, et al 28 | 100 mg/mL | 24 g | SWFI | SEQ 10 days at 4°C, then 24 hours at 22°C | Not Recorded |
| Richardson, B L, et al 52 | 40–333 mg/mL | 9.6–80g | SWFI | 24 hours at 25°C | Not Recorded |
| 20 mg/mL | 4.8 g | NS,5D | 24 hours at 25°C | ||
| Servais, H and P M Tulkens53 | 4%–8% w/v | 9.6–19.2g | SWFI | 24 hours at 21–25°C | Not Recorded |
| 10% | 24 g | SWFI | 24 hours at 21°C | ||
| 12% | 28.8 g | SWFI | 24 hours at 21°C, 24 hours at 25°C, 16 hours at 30°C | ||
| Stiles, M L, et al 21 | 36.6 mg/mL | 8.784 g | SWFI | SEQ 30 days at −20°C, then 4 days at 5°C, then 1 day at 37°C | Not Recorded |
| Stiles, M L, et al 6 | 30 mg/mL | 7.2 g | SWFI | SEQ (10 days at 3°C then 24 hours at 30°C), (7 days at 3°C then 16 hours at 30°C) | Not Recorded |
| 60 mg/mL | 14.4 g | SWFI | SEQ (30 days at −20°C then 4 days at 3°C then 1 day at 30°C), (10 days at 3°C 1 day at 30°C), (7 days at 3°C then 16 hours at 30°C) | ||
| Viaene, E, et al 20 | 8.3% w/v | 19.92 g | SWFI | 24 hours at 25°C | Recorded |
| 12% w/v | 28.8 g | SWFI | 24 hours at 25°C | ||
| Walker, S E, et al 54 | 5 mg/mL | 1.2 g | NS | 2 days at 23°C | Not Recorded |
| 5–40mg/mL | 1.2 g-9.6g | 5D | 1 day at 23°C | ||
| 60 mg/mL | 14.4 g | NS | 1 day and 23°C | ||
5D, 5% dextrose; PVC, polyvinyl chloride; SWFI, sterile water for injection.