Table 3

Experimental conditions verifying stability of selected carbapenems

Carbapenems Authors	Studied (C)	Dose in 240 mL	Diluent	Conditions under which >90% stability is confirmed
Doripenem
Berthoin, K, et al 31	1 g/100 mL	2.4 g	SWFI	24 hours at 25°C
Crandon, J L, et al 32	500 mg–1g/100 mL	1.2–2.4 g	NS	24 hours at 25°C
Crandon, J L, et al 32	500 mg–1g/100 mL	1.2–2.4 g	5D	16 hours at 25°C
Keel, R A, et al 55	5 mg/mL	1.2 g	NS	16 hours at 30°C, 12 hours at 35°C
Psathas, P A, et al 56	5 mg/mL	1.2 g	NS	12 hours at 25°C
Ertapenem
McQuade, M S, et al 57	10 mg/mL	2.4 g	NS	20 hours at 25°C
Meropenem
Berthoin, K, et al 31	1–4g/100 mL	2.4–9.6 g	SWFI	12 hours at 25°C
Carlier, M, et al 58	10–20 mg/mL	2.4–4.8 g	NS	12 hours at 25°C
Keel, R A, et al 55	5 mg/mL	1.2 g	NS	12 hours at 30°C
Mollá-Cantavella, S, et al 59	6–12 mg/mL	1.44–2.88 g	NS	12 hours at 25°C