Pharmacokinetic parameters after administration of a single oral dose of metoprolol tartrate 100 immediate release (IR) tablet (seven participants) and metoprolol succinate 95 mg controlled release (CR) tablet (five participants)
| Parameter | Metoprolol | α-OH metoprolol | ||||
| Mean±SD | Range | P value | Mean±SD | Range | P value | |
| Metoprolol IR | ||||||
| AUC0–10 hours (ng·hour/mL) | ||||||
| Pre-RYGB | 391±144 | 197–569 | 394±60 | 322–493 | ||
| Post-RYGB | 446±168 | 165–670 | 0.24 | 477±92 | 339–619 | 0.01 |
| Ratio | 1.19±0.43 | 0.74–1.98 | 1.21±0.14 | 1.05–1.36 | ||
| Cmax (ng/mL) | ||||||
| Pre-RYGB | 96±33 | 64–156 | 62±11 | 49–76 | ||
| Post-RYGB | 119±53 | 43–204 | 0.30 | 77±15 | 51–90 | 0.01 |
| Tmax (hour) | ||||||
| Pre-RYGB | 1.4±0.9 | 0.5–3.0 | 1.8±1.0 | 0.5–3.1 | ||
| Post-RYGB | 1.0±0.3 | 0.5–1.5 | 0.42 | 1.3±0.4 | 0.9–2.0 | 0.18 |
| Metoprolol CR | ||||||
| AUC0–24 hours (ng·hour/mL) | ||||||
| Pre-RYGB | 361±159 | 200–548 | 337±123 | 203–529 | ||
| Post-RYGB | 225±137 | 105–421 | <0.01 | 300±81 | 182–390 | 0.22 |
| Ratio | 0.59±0.13 | 0.43–0.77 | 0.91±0.10 | 0.74–0.98 | ||
AUC, area under the serum concentration versus time curve; RYGB, Roux-en-Y gastric bypass.