Table 3

Comparisons of serum vancomycin concentrations and pharmacokinetic parameters between the ECMO and non-ECMO groups

ECMO(n=75)Non-ECMO(n=69)P-values
Trough concentrations (mg/L)17.86±10.0410.94±6.93<0.001
Median (IQR)15.00 (10.50–24.20)8.30 (6.65–13.60)
 <5 mg/L, n (%)3 (4.0)5 (7.2)<0.001
 5–10 mg/L11 (14.7)37 (53.6)
 10–15 mg/L23 (30.7)14 (20.3)
 15–20 mg/L11 (14.7)8 (11.6)
 >20 mg/L27 (36)5 (7.2)
Peak concentrations (mg/L)
Median (IQR)
31.51±12.82
29.40 (21.60–39.70)
23.43±9.65
21.10 (16.85–27.20)
<0.001
Vd (L/kg)
Median (IQR)
0.63±0.30
0.55 (0.48–0.72)
0.57±0.14
0.56 (0.46–0.68)
0.596
t1/2 (hr)
Median (IQR)
17.45±11.01
13.70 (9.62–22.40)
5.92±2.70
5.50 (3.97–7.38)
<0.001
k (hr-1)0.06±0.040.14±0.06<0.001
CL (L/kg/hr)
Median (IQR)
0.03±0.02
0.03 (0.02–0.04)
0.08±0.05
0.07 (0.05–0.09)
<0.001
  • Data are presented as the mean±SD or median (IQR).

  • AUC24, area under the curve for 24 hr; CL, clearance of vancomycin related to weight; ECMO, Extracorporeal membrane oxygenation;IQR, interquartile range; Vd, volume of distribution related to weight; k, elimination rate constant; t1/2, half-life.