ECMO(n=75) | Non-ECMO(n=69) | P-values | |
Trough concentrations (mg/L) | 17.86±10.04 | 10.94±6.93 | <0.001 |
Median (IQR) | 15.00 (10.50–24.20) | 8.30 (6.65–13.60) | |
<5 mg/L, n (%) | 3 (4.0) | 5 (7.2) | <0.001 |
5–10 mg/L | 11 (14.7) | 37 (53.6) | |
10–15 mg/L | 23 (30.7) | 14 (20.3) | |
15–20 mg/L | 11 (14.7) | 8 (11.6) | |
>20 mg/L | 27 (36) | 5 (7.2) | |
Peak concentrations (mg/L) Median (IQR) | 31.51±12.82 29.40 (21.60–39.70) | 23.43±9.65 21.10 (16.85–27.20) | <0.001 |
Vd (L/kg) Median (IQR) | 0.63±0.30 0.55 (0.48–0.72) | 0.57±0.14 0.56 (0.46–0.68) | 0.596 |
t1/2 (hr) Median (IQR) | 17.45±11.01 13.70 (9.62–22.40) | 5.92±2.70 5.50 (3.97–7.38) | <0.001 |
k (hr-1) | 0.06±0.04 | 0.14±0.06 | <0.001 |
CL (L/kg/hr) Median (IQR) | 0.03±0.02 0.03 (0.02–0.04) | 0.08±0.05 0.07 (0.05–0.09) | <0.001 |
Data are presented as the mean±SD or median (IQR).
AUC24, area under the curve for 24 hr; CL, clearance of vancomycin related to weight; ECMO, Extracorporeal membrane oxygenation;IQR, interquartile range; Vd, volume of distribution related to weight; k, elimination rate constant; t1/2, half-life.