Vancomycin concentration (mg/mL) | Solvent for reconstitution | Cumulative quantity (mg) at 24 hours, median (IQR) (% loss±SD) | P value | |||
WFI vs saline solution | F vs NF | |||||
With filter | Without filter | F | NF | |||
25 | WFI | 452 (2) (6.2±0.8) | 444 (5) (7.1±0.6) | 0.063 | 0.905 | 0.071 |
Saline solution | 447 (2) (7.1±0.5) | 448 (4) (7.1±1.6) | 0.690 | |||
40 | WFI | 1663 (5) (13.5±0.5) | 1662 (4) (13.4±0.1) | 0.012* | 0.008* | 0.802 |
Saline solution | 1645 (6) (14.3±0.3) | 1651 (8) (14.0±0.6) | 0.087 | |||
60 | WFI | 2563 (2) (11.0±0.3) | 2601 (10) (9.7±0.2) | 0.012* | 0.008* | 0.008* |
Saline solution | 2531 (4) (12.1±0.4) | 2550 (1) (11.5±1.1) | 0.012* | |||
80 | WFI | 3314 (4) (13.7±0.1) | 3284 (1) (14.4±0.3) | NA | NA | 0.012* |
Saline solution | NA | NA | NA |
*P<0.05.
F, filtered; NA, not applied; NF, non-filtered; WFI, water for injection.