Table 2

Mass balance of ketamine solutions after various stressed degradations.

Area
Peaks	Retention time (minutes)	Relative retention	Without stressed degradation	Acidic degradation	Alkaline degradation	Oxydative degradation	Heat degradation	Photolyse degradation
Peaks	Retention time (minutes)	Relative retention	Without stressed degradation	HCl 30% 85°C 48 hours	NaOH 1M 85°C 48 hours	H₂O₂ 30% 48 hours	85°C 48 hours	254 nm 3 hours
Kétamine	7.83	1.00	13 800 130	13 681 605	12 092 994	13 314 459	14 338 895	12 123 551
1	1.9	0.24						20 538
2	2.2	0.28				67 650		51 200
3	2.5	0.32				33 160
4	2.75	0.35						46 660
5	3	0.38				157 927		139 337
6	3.8	0.49						33 399
7	4.45	0.57						18 708
8	4.9	0.63						18 787
9	5.15	0.66			542 851			54 982
10	5.65	0.72						128 672
11	6.3	0.80			6 053	9 499	83 063	9 093
12	6.45	0.82	11 498
13	7	0.89						36 029
14	25.7	3.28						2 015 360
Mass balance			13 811 628	13 681 605	12 641 898	13 582 695	14 421 958	14 696 316
% degradation				1%	12%	4%	0%*	12%

*No degradation was observed for heat degradation. The higher peak surface found is due to the increase of the concentration, probably caused by the evaporation of the solvent.