Evolution of osmolality for each vancomycin condition (n=3 syringes)
| Vancomycin concentration (mg/mL) | Solvent for reconstitution | With filter (mOsmol/kg) | Without filter (mOsmol/kg) | ||||
| T0 | T24 | P value | T0 | T24 | P value | ||
| 25 | WFI | 176 (1) | 177 (1) | 0.800 | 174 (1) | 175 (3) | 0.800 |
| Saline solution | 319 (2) | 324 (2) | 0.200 | 319 (3) | 314 (2) | 0.600 | |
| 40 | WFI | 95 (1) | 98 (1) | 0.200 | 92 (2) | 91 (1) | 0.800 |
| Saline solution | 323 (1) | 326 (2) | 0.300 | 326 (2) | 327 (1) | 0.700 | |
| 60 | WFI | 74 (1) | 76 (1) | 0.300 | 73 (1) | 74 (2) | 1.000 |
| Saline solution | 351 (2) | 354 (1) | 0.600 | 354 (2) | 357 (1) | 0.100 | |
| 80 | WFI | 72 (1) | 76 (1) | 0.100 | 72 (1) | 75 (1) | 0.072 |
| Saline solution | 349 (1) | 352 (1) | 0.072 | 352 (1) | 350 (2) | 0.300 | |
Data are presented as median (IQR).
T0, at time 0; T24, at 24 hours; WFI, water for injection.