Table 3

Evolution of osmolality for each vancomycin condition (n=3 syringes)

Vancomycin concentration (mg/mL)Solvent for reconstitutionWith filter (mOsmol/kg)Without filter (mOsmol/kg)
T0T24P valueT0T24P value
25 WFI176 (1)177 (1)0.800174 (1)175 (3)0.800
Saline solution319 (2)324 (2)0.200319 (3)314 (2)0.600
40 WFI95 (1)98 (1)0.20092 (2)91 (1)0.800
Saline solution323 (1)326 (2)0.300326 (2)327 (1)0.700
60 WFI74 (1)76 (1)0.30073 (1)74 (2)1.000
Saline solution351 (2)354 (1)0.600354 (2)357 (1)0.100
80 WFI72 (1)76 (1)0.10072 (1)75 (1)0.072
Saline solution349 (1)352 (1)0.072352 (1)350 (2)0.300
  • Data are presented as median (IQR).

  • T0, at time 0; T24, at 24 hours; WFI, water for injection.