Table 2

Demographic and clinical characteristics of patients

Pairs of drug concentrations (peak and trough)7569
Gestational age, weeks39.01±1.1138.80±1.140.511
Postnatal age, days8.00±7.9410.72±8.070.235
Postconceptional age, weeks40.15±1.4040.33±1.470.664
Males, n (%)14/25 (56)18/25 (72)0.239
Bodyweight, kg3.06±0.363.04±0.360.721
PRISM III score at 24 hours (range)13.92±4.80 (3–23)11.04±5.40 (4–27)0.052
Length of PICU stay, days (range)17.44±10.66 (5–45)17.56±11.24 (4–54)0.965
PICU survival, n (%)5 (20)21 (84)<0.001
Underlying disease0.004
 Congenital heart disease1322
 Lung disorder120
 Endocrine disorder01
 Haematologic disorder01
Duration of vancomycin therapy, days (range)18.96±9.17 (4–38)20.17±9.12 (3–36)0.428
Serum creatinine, mg/dL (range)1.03±0.700.34±0.14<0.001
Median (IQR)0.70 (0.50–1.40)0.32 (0.24–0.43)
Renal replacement0.001
 Without dialysis, n (%)3964
 CRRT, n (%)160
 Haemofiltration, n (%)150
 PD, n (%)15
  • Data are presented as the mean±SD (range) or n (%).

  • CRRT, continuous replacement therapy; ECMO, extracorporeal membrane oxygenation; IQR, interquartile range; PD, peritoneal dialysis; PRISM, paediatric risk of mortality; PICU, paediatric intensive care unit.