ECMO | Non-ECMO | P values | |
Patients | 13 | 26 | |
Cases | 17 | 56 | |
Vd (L/kg) | 0.75±0.41 | 0.59±0.14 | 0.069 |
t1/2 (hr) Median (IQR) | 11.52±6.31 10.59 (6.70–14.75) | 5.44±2.36 5.06 (3.70–6.71) | <0.001 |
k (hr-1) | 0.08±0.04 | 0.15±0.06 | <0.001 |
CL (L/kg/hr) Median (IQR) | 0.05±0.02 0.05 (0.03–0.06) | 0.09±0.05 0.08 (0.06–0.10) | 0.001 |
Data are presented as the mean±SD or median (IQR).
CL, clearance of vancomycin related to weight; ECMO, extracorporeal membrane oxygenation;IQR, interquartile range; SCr, serum creatinine; Vd, volume of distribution related to weight; k, elimination rate constant; t1/2, half-life.