Table 5

Vancomycin pharmacokinetic parameters in neonates with SCR <0.5 mg/dL

ECMONon-ECMOP values
Patients1326
Cases1756
Vd (L/kg)0.75±0.410.59±0.140.069
t1/2 (hr)
Median (IQR)
11.52±6.31
10.59 (6.70–14.75)
5.44±2.36
5.06 (3.70–6.71)
<0.001
k (hr-1)0.08±0.040.15±0.06<0.001
CL (L/kg/hr)
Median (IQR)
0.05±0.02
0.05 (0.03–0.06)
0.09±0.05
0.08 (0.06–0.10)
0.001
  • Data are presented as the mean±SD or median (IQR).

  • CL, clearance of vancomycin related to weight; ECMO, extracorporeal membrane oxygenation;IQR, interquartile range; SCr, serum creatinine; Vd, volume of distribution related to weight; k, elimination rate constant; t1/2, half-life.